ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Graphene Nanosensor for the Detection of Small Organic Compounds Using an Insect Olfactory Receptor.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Insect olfactory receptors have evolved to detect a wide range of chemicals and biomolecules, offering a promising foundation for next-generation chemical sensors. We report the first direct integration of the odorant receptor MhOR5 from Machilis hrabei onto a graphene field-effect transistor (gFET) for selective, label-free detection of small organic compounds (SOCs). Large scale production of MhOR5 was achieved for the first time, yielding a stable tetrameric protein (80% purity) with up to 3-month stability. High-quality gFETs were fabricated at the wafer scale and quality controlled before utilization, demonstrating highly reproducible chips. The MhOR5-functionalized gFETs were tested against sixteen chemically diverse SOCs, including eugenol, DEET, hexanol, and octanol, across a concentration range of 200 nm to 10 mm. Each analyte induced a concentration-dependent response in the sensor. Binding analysis within the tested SOCs revealed the strongest affinity for acetophenone (logK
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