ArticleMediators of inflammation2026
Acupuncture Treatment Alleviating Pyroptosis on Asthma Inflammation in Mice via Micro-RNA-223/NLRP3 Pathway.
Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Acupuncture Treatment Alleviating Pyroptosis on Asthma Inflammation in Mice via Micro-RNA-223/NLRP3 Pathway.Mediators of inflammation · 2026Article
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Authors and funding
7 authors.
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Abstract
backgroundEvidence has shown that acupuncture treatment could significantly reduce the activation inflammation in asthmatic mice. However, the underlying mechanism through which acupuncture influences asthma has not yet been elucidated.
methodsOVA-induced asthma in NLRP3
resultsIn vitro, acupuncture treatment alleviated airway inflammation in asthmatic mice, upregulated miR-223 expression, inhibited the genes and proteins expression level in NLRP3 pathway, such as NLRP3, GSDMD, ASC, and Caspase-1, it also lowered the presence of cytokines tied to T cells. Activation of the NLRP3 pathway seemed to make asthma symptoms worse, whereas acupuncture treatment effectively alleviated the inflammation by modulating the miR-223/NLRP3 pathway. In vivo, after upregulating or downregulating miR-223 expression in an LPS-induced cell inflammation model, the expression levels of the NLRP3 pathway changed significantly. The dual-luciferase assay revealed the specific interaction of miR-223 to the NLRP3 gene, thereby suppressing its transcription.
conclusionsmiR-223-3p can bind to NLRP3 and suppresses the expression of NLRP3 gene. Acupuncture treatment can activate miR-223/NLRP3-related pyroptosis pathway to regulate T-lymphocyte immunity and effectively reduce airway inflammation in asthmatic mice.
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