Evidence map›Paper›PMID 42438363›Full record

ArticleProtein science : a publication of the Protein Society2026

Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.

Maximilian Fröhlich, Tamara Radišković, Valentina Hopl, Magdalena Prantl, Hadil Najjar, Selina Harant, Diana Thallinger, Muhammad Shehzad Anwar, Ferdinand Horvath, Julia Söllner and 8 more

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Maximilian FröhlichJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Tamara RadiškovićJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Valentina HoplJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Magdalena PrantlJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Hadil NajjarJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Selina HarantJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Diana ThallingerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Muhammad Shehzad AnwarJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Ferdinand HorvathInstitute of Theoretical Physics, Johannes Kepler University Linz, Linz, Austria.
Julia SöllnerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Yuliia NazarenkoJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Matthias SallingerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Nora MüllerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Adéla TiffnerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Sarah WeißJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Herwig GrabmayrJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.
Heinrich KrobathInstitute of Theoretical Physics, Johannes Kepler University Linz, Linz, Austria.
Isabella DerlerJKU Life Science Center, Institute of Biophysics, Johannes Kepler University Linz, Linz, Austria.

Funding

Austrian Science Fund https://doi.org/10.55776/P35900Austrian Science Fund https://doi.org/10.55776/P36202Austrian Science Fund https://doi.org/10.55776/PAT6871323Österreichischen Akademie der Wissenschaften Nora Müller
6 · The paper itself

Abstract

The calcium (Ca

Indexed as

Evolution, MolecularNeoplasm ProteinsORAI1 ProteinStromal Interaction Molecule 1CalciumHEK293 CellsHumansHydrophobic and Hydrophilic InteractionsCalciumNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1CRAC channelhydrophobicityOrai1pore openingsterics

Identifiers

PMID42438363
PMCPMC13358370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.