ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2026
PHLPP is neither a Phosphatase nor a Tumor Suppressor.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
PH domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/PHLPP2) have, for more than 20 years, been described as Akt phosphatases and tumor suppressor genes. Approximately 200 PubMed-indexed articles have been published on the topic, including efforts to pharmacologically inhibit PHLPP in disease settings. A recent study, however, presents evidence that PHLPP is actually a pseudophosphatase with no catalytic activity. These observations question its reported role in cancer. The designation of PHLPP1 and PHLPP2 as pseudophosphatases necessitates both a critical examination of the literature and new hypotheses for the biological function of these ancient proteins. Here, we review the emergence of PHLPP1 and PHLPP2 as cellular signal transducers, critically examine the evidence for their reported phosphatase activity and tumor suppressor functions, and propose steps to elucidate their biological functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.