Evidence map›Paper›PMID 42438091›Full record

ArticleMolecular plant pathology2026

The Transcription Factor DPB Confers Antiviral Defence Against Potato Virus X by Modulating MYB-Dependent Signalling.

Jingjing Shi, Yumei Zhao, Chunyan Qi, Yaoyao Jiang, Bin Yong, Lingyun Lei, Wenhao Wang, Peng Liu, Jiaqian Liu, Tianye Zhang and 4 more

Abstract read
In one paragraph

Article in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Jingjing ShiState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Yumei ZhaoState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Chunyan QiState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Yaoyao JiangState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Bin YongState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Lingyun LeiMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, China.
Wenhao WangLuohe Academy of Agricultural Science, Luohe, China.
Peng LiuState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Jiaqian LiuState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.
Tianye ZhangState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.ORCID 0000-0002-0699-3117
Jianping ChenState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.ORCID 0000-0002-3849-4080
Jian YangState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.ORCID 0000-0002-4456-7231
Tianbo LiuTobacco Research Institute of Hunan Province, Changsha, Hunan, China.
Kaili ZhongState Key Laboratory for Quality and Safety of Agro-Products, Key Laboratory of Biotechnology in Plant Protection of MARA, Key Laboratory of Green Plant Protection of Zhejiang Province, Institute of Plant Virology, Ningbo University, Ningbo, China.

Funding

National Key Research and Development Program of China 2023YFD1400300Natural Science Foundation of Ningbo Municipality 2023J382
6 · The paper itself

Abstract

As a transcriptional co-factor of E2F, DP proteins are typically involved in the regulation of plant cell-cycle-related processes. However, whether DP proteins participate in transcriptional regulation associated with plant antiviral defence remains largely unclear. This study demonstrates that NbDPB, a DP family protein in Nicotiana benthamiana, positively regulates resistance to potato virus X (PVX) by functioning as a transcription factor. Knockout of NbDPB increased plant susceptibility to PVX, while its overexpression significantly suppressed viral accumulation. Furthermore, we identified that NbDPB binds to the promoter of NbMYB (a MYB transcription factor) and positively regulates its expression. Silencing NbMYB enhanced PVX infection, whereas exogenous application of jasmonic acid (JA) and salicylic acid (SA) partially rescued this phenotype. Hormone levels of JA and SA, as well as the expression levels of their marker genes, were significantly reduced in the silenced NbMYB plants. These findings suggest that the NbDPB-NbMYB module mediates antiviral defence through the JA and SA signalling pathways. This study reveals a previously uncharacterized role of DP proteins in antiviral transcriptional regulation, indicating that they may play a crucial role in plant antiviral defence.

Indexed as

NicotianaPlant DiseasesPlant ProteinsPotexvirusSignal TransductionTranscription FactorsCyclopentanesGene Expression Regulation, PlantGene SilencingOxylipinsPromoter Regions, GeneticProtein BindingSalicylic AcidCyclopentanesjasmonic acidOxylipinsPlant ProteinsSalicylic AcidTranscription Factors

Identifiers

PMID42438091
PMCPMC13357984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.