Evidence map›Paper›PMID 42437700›Full record

ArticleChemMedChem2026

Synthesis and Biological Evaluation of Indole-Benzene Sulfonamides as Carbonic Anhydrase II, IX, and XII Inhibitors.

Vadakattu Manasa, Sabesan Jayaprakash, Niccolo Paoletti, Danaboina Srikanth, Nitesh Tamang, Devandla Soujanya, Mahammad Ghouse Shaik, Venkata Madhavi Yaddanapudi, Claudiu T Supuran, Srinivas Nanduri

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In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vadakattu ManasaDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Sabesan JayaprakashDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.ORCID https://orcid.org/0009-0000-9200-9923
Niccolo PaolettiNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università Degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.ORCID https://orcid.org/0000-0002-6874-9419
Danaboina SrikanthDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Nitesh TamangDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Devandla SoujanyaDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.
Mahammad Ghouse ShaikDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0002-7907-4250
Venkata Madhavi YaddanapudiDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0002-9813-8694
Claudiu T SupuranNeurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università Degli Studi di Firenze, Sesto Fiorentino, Florence, Italy.ORCID https://orcid.org/0000-0003-4262-0323
Srinivas NanduriDepartment of Chemical Sciences, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, Telangana, India.ORCID https://orcid.org/0000-0002-6671-2022

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human carbonic anhydrases (hCAs) are zinc-bound enzymes that play a critical role in pH regulation and ion balance. Among them, isoforms hCA IX and XII are overexpressed in tumor hypoxia and are implicated in tumor progression. In this study, new indole-benzenesulfonamide derivatives with hydrazide and amide linkers were synthesized and evaluated against hCA I, II, IX, and XII. Among them, compounds 5c and 5o showed potent inhibition against hCA IX with K

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesIndolesSulfonamidesAntigens, NeoplasmBenzenesulfonamidesCarbonic Anhydrase IICarbonic Anhydrase IXDose-Response Relationship, DrugHumansIsoenzymesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntigens, NeoplasmBenzenesulfonamidesCA9 protein, humanCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic Anhydrase IXCarbonic Anhydrasescarbonic anhydrase XIIindoleIndolesIsoenzymesSulfonamidescarbonic anhydraseshuman carbonic anhydrase IX and XIhydrazideshypoxic tumorindole‐benzenesulfonamide

Identifiers

PMID42437700
PMCPMC13357036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.