Evidence map›Paper›PMID 42437668›Full record

ArticleBone & joint research2026

Exercise-primed Trpv4+ progenitors sense mechanical to regulate graded transition in enthesis regeneration.

Shibo Xu, Yiyi Lin, Yihang Yu, Zhiquan Zhu, Pan Huang, Qizhong Xie, Yujianan Chen, Xu Tao, Mei Zhou, Zunhan Liu and 2 more

Abstract read
In one paragraph

Article in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shibo XuState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0009-0006-3995-0830
Yiyi LinDepartment of Otorhinolaryngology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0009-0008-2741-447X
Yihang YuState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0009-0008-9480-075X
Zhiquan ZhuState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0009-0001-9942-9637
Pan HuangState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0000-0001-8264-6363
Qizhong XieDepartment of Orthopaedics, The 901th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army, Hefei, China.ORCID 0009-0003-2367-6185
Yujianan ChenState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0009-0003-8640-9463
Xu TaoState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0000-0002-1661-8652
Mei ZhouState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0000-0003-3936-463X
Zunhan LiuState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0009-0009-1803-4966
Xuting BianState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0000-0002-9234-4913
Lin GuoState Key Laboratory of Trauma, Burn and Combined Injury, Department of Orthopedics/Sports Medicine Center, First Affiliated Hospital of Army Medical University, Chongqing, China.ORCID 0000-0003-4718-6706

Funding

National Natural Science Foundation of ChinaNatural Science Foundation Program of Chongqing
6 · The paper itself

Abstract

Aims: To identify the molecular mechanisms of mechanotransduction that drive functional regeneration rather than scar formation at the tendon-bone interface, addressing the high clinical failure rates of enthesis injuries. Methods: Single-cell RNA sequencing was performed on enthesis tissues at multiple post-injury timepoints. A mouse tendon-bone insertion injury model was established with treadmill exercise versus sedentary controls. Transient receptor potential vanilloid 4 (TRPV4)+ cells were isolated by fluorescence-activated cell sorting for functional assays. Mechanistic studies included bulk RNA sequencing, immunofluorescence, and in vitro mechanical stimulation. Functional outcomes were assessed by histomorphometry, micro-CT, and biomechanical testing. Results: Single-cell transcriptomics identified Conclusion:

Identifiers

PMID42437668
PMCPMC13356974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.