Evidence map›Paper›PMID 42437522›Full record

ReviewBiotechnology and bioengineering2026

Challenges and Future Directives of Synthetic Biology in Engineering Plant-Microbe Partnerships for Sustainable Agriculture.

Ben Jesuorsemwen Enagbonma, Rebaona Reaobaka Molefe-Madlaliso, Alaba Adewole Adebayo, Oghoye Priscilla Oyedoh, Godfrey Okainemen Oribhabor, Oluwaseun Emmanuel Shittu, Olubukola Oluranti Babalola

Abstract readReview
In one paragraph

Review in Biotechnology and bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ben Jesuorsemwen EnagbonmaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0002-4699-5061
Rebaona Reaobaka Molefe-MadlalisoFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0003-3192-0419
Alaba Adewole AdebayoFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0002-5768-6539
Oghoye Priscilla OyedohFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0002-8330-0089
Godfrey Okainemen OribhaborFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0003-2917-7662
Oluwaseun Emmanuel ShittuFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0009-0003-6388-5387
Olubukola Oluranti BabalolaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, North West Province, South Africa.ORCID https://orcid.org/0000-0003-4344-1909

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production. Thus, we examined the challenges limiting synthetic biology applications in engineering plant-microbe partnerships and highlighted future research directions. Ecological, biological, technical, and regulatory barriers to synthetic biology-driven plant-microbe engineering are the challenges examined in this review. Profound insight into these challenges will lead to a shift toward systems-level approaches that integrate multiomics analyses, predictive modeling, and framework-responsive genetic designs. To completely translate synthetic biology from the laboratory to the field, improved delivery methods, monitoring strategies, and harmonized regulatory frameworks should be encouraged. In addition, the development of robust and controllable microbial chassis should be emphasized.

Indexed as

AgriculturePlantsSynthetic Biologycomplianceecosafetyhost–microbe compatibilitymicrobial consortiamultiomics

Identifiers

PMID42437522
PMCPMC13576769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.