Evidence map›Paper›PMID 42437431›Full record

ArticleInternational ophthalmology2026

Risk factors for iatrogenic retinal breaks during induction of posterior vitreous detachment in macula surgery.

Jai Ethan Paris, Carmelo Zak Macri, Surbhi Agrawal, Stewart Lake, Weng Onn Chan

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Article in International ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jai Ethan ParisDiscipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia. jai.paris@student.adelaide.edu.au.
Carmelo Zak MacriDiscipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.
Surbhi AgrawalDiscipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.
Stewart LakeDepartment of Ophthalmology, Flinders Medical Centre, Adelaide, SA, Australia.
Weng Onn ChanDiscipline of Ophthalmology and Visual Sciences, The University of Adelaide, Adelaide, SA, 5005, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine risk factors for retinal breaks (RB) during the surgical induction of posterior vitreous detachment (IPVD) in macula surgery.

methodsWe retrospectively reviewed electronic records for all adult patients undergoing 25-G or 27-G vitrectomy for macula pathology between November 2019 and January 2024 requiring intraoperative IPVD. We excluded eyes with pre-existing PVD, panretinal photocoagulation, trauma, age < 18 years or missing information. The outcome measure was non-sclerotomy-related iatrogenic RB. We assessed the effect of age, gauge size (25-G vs 27-G), surgical indication (epiretinal membrane [ERM] vs macular hole[MH]/vitreomacular traction syndrome[VMTS]), lens status (Phakic vs Aphakic/Pseudophakic) and surgeon (Consultant vs Fellow) on the odds of RB.

resultsAmong 185 eyes included in our study, 15.1% experienced a RB during IPVD. Breaks were predominantly located in the inferior retina (69%). Multivariable analysis revealed gauge size significantly impacted RB rate (27-G OR 0.13 95%CI 0.03-0.60, p = 0.008). Other factors including age (OR 0.98 95%CI 0.96-1.01, p = 0.18), lens status (Phakic OR 0.36 95%CI 0.13-1.01, p = 0.053), surgeon grade (Fellow OR 1.8 95%CI 0.18-18.9, p = 0.61) and surgical indication (MH OR 0.70 95%CI 0.30-1.7, p = 0.42) were not significantly associated with odds of RB.

conclusionsThere is a high rate of iatrogenic RB in eyes requiring IPVD undergoing macula surgery. Smaller instrument gauge size was associated with lower odds of RB during IPVD, however causal inferences cannot be drawn from these findings. Neither age, surgical indication nor lens status were associated with odds of RB.

Indexed as

Iatrogenic DiseaseIntraoperative ComplicationsMacula LuteaRetinal PerforationsVisual AcuityVitrectomyVitreous DetachmentAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsPosterior vitreous detachmentRetinal breakRetinal detachmentSurgical techniqueVitrectomy

Identifiers

PMID42437431
PMCPMC13357438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.