Evidence map›Paper›PMID 42437294›Full record

ArticleRegenerative therapy2026

CXCL12-abundant reticular cell lineage is the key source of endosteal osteoblasts and adipocytes in adult bone marrow.

Takumi Shibahara, Katsutoshi Hirose, Makoto Abe, Yu Usami, Miho Hyodo, Yoshiaki Hayashi, Daisuke Motooka, Kanta Wakamori, Narikazu Uzawa, Shinsuke Ohba and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takumi ShibaharaDepartment of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Katsutoshi HiroseDepartment of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Makoto AbeDepartment of Tissue and Developmental Biology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yu UsamiDepartment of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Miho HyodoDepartment of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Yoshiaki HayashiNGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Daisuke MotookaNGS Core Facility, Research Institute for Microbial Diseases, The University of Osaka, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Kanta WakamoriDepartment of Oral & Maxillofacial Oncology and Surgery, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Narikazu UzawaDepartment of Oral & Maxillofacial Oncology and Surgery, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Shinsuke OhbaDepartment of Tissue and Developmental Biology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Satoru ToyosawaDepartment of Oral and Maxillofacial Pathology, The University of Osaka Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: CXCL12-abundant reticular (CAR) cells, characterized by high expression of CXCL12, are perisinusoidal bone marrow stromal cells that establish the hematopoietic stem cell niche. Although CAR cells are postulated to become precursor cells of both osteoblasts and adipocytes, the spatiotemporal dynamics of CAR cells-particularly their contribution to osteoblasts-remain poorly understood. Here, we defined the contribution of the endogenous Methods: A novel Results: Lineage tracing revealed that the Cxcl12 Conclusions: The

Indexed as

AdipocyteBone marrow stromal cellCAR cellCxcl12Leptin receptorOsteoblast

Identifiers

PMID42437294
PMCPMC13355666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.