Evidence map›Paper›PMID 42437287›Full record

ArticleJournal of the American College of Emergency Physicians open2026

Preparing Emergency Medical Services for Prehospital Buprenorphine: Examining a Train-the-Trainer Approach to Strengthening the Overdose Chain of Survival.

Maria E Paschke, Saad T Siddiqui, Joshua Wilson, Gerard Carroll, Melissa Kroll, Bradley Ray, Rachel P Winograd

Abstract read
In one paragraph

Article in Journal of the American College of Emergency Physicians open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria E PaschkeMissouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA.
Saad T SiddiquiMissouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA.
Joshua WilsonMissouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA.
Gerard CarrollDepartment of Emergency Medicine, Cooper University Hospital, Cooper Medical School at Rowan University, Camden, New Jersey, USA.
Melissa KrollWashington University School of Medicine, St. Louis, Missouri, USA.
Bradley RayResearch Triangle Institute (RTI) International, Durham, North Carolina, USA.
Rachel P WinogradMissouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Opioid-related overdoses remain the leading cause of accidental death in the US. Many jurisdictions are exploring emergency medical services (EMS)-initiated prehospital buprenorphine induction at overdose scenes to reduce subsequent risk. This study evaluated a training strategy preparing EMS agencies to implement these protocols by examining barriers and facilitators affecting their readiness to integrate buprenorphine into standard care. Methods: Leadership from 6 Missouri EMS agencies participated in a 6-month training program to support prehospital buprenorphine implementation. We described this evidence-informed frame-and-foster training approach and present findings from a readiness checklist and interviews with 8 trainees. Analysis followed a deductive, exploration, preparation, implementation, sustainment (EPIS)-guided framework approach to assess trainees' perceptions of the training and inner and outer barriers and facilitators to agency-wide implementation. Results: All agencies reported readiness, with (1) frontline staff training and (2) partnering with peer-linkage programs as areas for further preparation. Training increased confidence and clarified workflows. Remaining inner barriers within EMS agencies included stigma among paramedics toward people who use drugs, staff resistance, and burnout, while facilitators included clear protocols and integration into community paramedicine programs. Outer barriers included inconsistent community buprenorphine availability, while facilitators included continued training and state support. Conclusions: This evaluation provides early insights into how a structured training strategy can prepare EMS agencies to implement prehospital buprenorphine. Findings can inform future policy and practice to ensure EMS can effectively incorporate buprenorphine induction into overdose response and improve patient outcomes.

Indexed as

buprenorphinecapacity buildingemergency medical servicesimplementation scienceopiate overdoseprogram developmentsubstance-related disorders

Identifiers

PMID42437287
PMCPMC13355182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.