ArticleCureus2026
Cytotoxic Lesions of the Corpus Callosum: A Single-Center Case Series of Eight Patients With an Emphasis on Infectious Etiologies.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim Cytotoxic lesions of the corpus callosum (CLOCCs) are transient lesions characterized by restricted diffusion on MRI and are associated with various infectious and noninfectious conditions. However, the clinical spectrum of infection-related CLOCCs, particularly those associated with bacterial infections, remains incompletely defined. This study aimed to describe the clinical, etiological, and neuroimaging characteristics of CLOCCs diagnosed at a single center, encompassing both infectious and noninfectious etiologies, with particular attention to infection-related cases. Methods We retrospectively reviewed patients diagnosed with CLOCCs at Jichi Medical University Saitama Medical Center between January 2016 and May 2025. Patients were identified by searching institutional radiology reports and electronic medical records for callosal lesions, followed by review of the corresponding records. Clinical characteristics, underlying etiologies, laboratory findings, MRI features, treatment, follow-up imaging, and clinical outcomes were extracted from medical records. Results Eight patients were identified (median age, 47.5 years; range, 12-70; five male and three female). Five patients had infection-related CLOCCs, including bacteremia, meningoencephalitis, and COVID-19-associated myocarditis. One patient had
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