ArticleCureus2026
Large Pericardial Effusion As the Initial Presentation of Mixed Connective Tissue Disease in a Severely Malnourished Patient: A Diagnostic Challenge.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Pericardial effusion, defined as the abnormal accumulation of fluid within the pericardial sac, has a broad differential diagnosis, and identifying the underlying etiology can be particularly challenging when multiple potential causes coexist. Mixed connective tissue disease (MCTD) is a rare systemic autoimmune disorder. MCTD is characterized by overlapping features of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis in association with anti-U1 ribonucleoprotein antibodies (anti-U1-RNP). Although pericarditis is the most common cardiac manifestation of MCTD, large pericardial effusion as the initial presenting feature has been described in only a small number of case reports. We describe the case of a 62-year-old malnourished female (BMI 17.7 kg/m
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