Evidence map›Paper›PMID 42437198›Full record

ArticleCurrent developments in nutrition2026

Air Pollution Mixture and Folate Status Indicators among Pregnant Women in Canada: Maternal-Infant Research on Environmental Chemicals (MIREC) Study, 2008 to 2011.

Tyler Js Smith, Hachem Saddiki, Joseph M Braun, Amanda J MacFarlane, Eric Lavigne, Markey Johnson, Ana Maria Siega-Riz, Raji Balasubramanian, Mandy Fisher, R Thomas Zoeller and 4 more

Abstract read
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In one paragraph

Article in Current developments in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tyler Js SmithDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Hachem SaddikiDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Joseph M BraunDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, United States.
Amanda J MacFarlaneNutrition Research Division, Health Canada, Ottawa, ON, Canada.
Eric LavigneEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Markey JohnsonWater and Air Quality Bureau, Health Canada, Ottawa, ON, Canada.
Ana Maria Siega-RizDepartment of Biostatistics & Epidemiology, University of Massachusetts at Amherst School of Public Health & Health Sciences, Amherst, MA, United States.
Raji BalasubramanianDepartment of Biostatistics & Epidemiology, University of Massachusetts at Amherst School of Public Health & Health Sciences, Amherst, MA, United States.
Mandy FisherEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
R Thomas ZoellerDepartment of Biology, University of Massachusetts at Amherst School of Public Health & Health Sciences, Amherst, MA, United States.
Jillian Ashley-MartinEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Tye E ArbuckleEnvironmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Bruce P LanphearFaculty of Health Sciences, Simon Fraser University, Vancouver, BC, Canada.
Youssef OulhoteDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Folic acid (FA) has been reported to modify associations between air pollutants and autism, but no study has investigated whether air pollutants are associated with maternal folate status. Objectives: We estimated associations between an air pollution mixture and maternal folate status among pregnant women in Canada. Methods: We enrolled pregnant women ( Results: Among complete cases in the first and third trimesters ( Conclusions: Air pollution was positively associated with total folate concentrations and UMFA proportions and negatively associated with 5MTHF proportions. Associations were strongest in the third trimester and among pregnant women carrying female fetuses. Air pollution may influence maternal folate status during pregnancy.

Indexed as

air pollutionfolate statusfolic acid supplementationmixturesprenatal nutrition

Identifiers

PMID42437198
PMCPMC13355500

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.