Unique presentation of immune thrombocytopenic purpura in adult osteopetrosis: A case report.

Shane Johns, Joanna Fair, Austin R Pantel, Thomas M Anderson

Abstract readCase Reports

In one paragraph

Article in Radiology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shane JohnsSchool of Medicine, University of New Mexico, 915 Camino de Salud NE, Albuquerque, New Mexico, 87106.

Joanna FairDepartment of Radiology, University of New Mexico, UNM Hospital, 2211 Lomas Blvd NE, Albuquerque, New Mexico, 87106.

Austin R PantelDepartment of Radiology, University of Pennsylvania, Hospital of the University of Pennsylvania, 3400 Spruce Street, 1 Silverstein, Ste. 130, Philadelphia, Pennsylvania, 19104.

Thomas M AndersonDepartment of Radiology, University of New Mexico, UNM Hospital, 2211 Lomas Blvd NE, Albuquerque, New Mexico, 87106.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteopetrosis is a genetic disorder characterized by impaired osteoclast function, leading to diffuse osteosclerosis, brittle bones, and hematologic abnormalities. Herein, we report the case of a 55-year-old woman diagnosed with adult-onset osteopetrosis at age 33 after imaging demonstrated dense and marbled long bones, sclerotic medullary canals, vertebral endplate thickening, and hepatosplenomegaly. Bone marrow biopsy revealed preserved megakaryocytes, yet she experienced recurrent episodes of thrombocytopenia that responded to oral steroids and ultimately resolved following splenectomy, supporting an immune-mediated etiology of thrombocytopenia clinically managed as immune thrombocytopenic purpura. The clinical course was further complicated by multiple periprosthetic fractures, highlighting both the diagnostic and management challenges of this condition.

Indexed as

Adult-onset osteopetrosisBone marrow failureBone scintigraphyImmune thrombocytopenic purpuraOsteopetrosisPeriprosthetic fractures

Identifiers

PMID42437155

DOI10.1016/j.radcr.2026.06.065

PMCPMC13355600

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.