ArticleOphthalmology science2026
Age- and Myopia-Related 3-Dimensional Remodeling of Choroidal Thickness in Children.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Purpose: To investigate the 3-dimensional (3D) topographic remodeling patterns of choroidal thickness (ChT) in the macular region in children, and their associations with age and myopia related ocular growth. Design: Cross-sectional, population-based study. Participants: A total of 3508 children (mean age 13.6 ± 3.0 years, range 7-18 years, 47.7% male). Methods: Spectral-domain OCT with a 31-horizontal B-scan protocol was performed on right eyes. Choroidal thickness in each B-scan was automatically segmented and quantified using modified open-source deep learning algorithms (Choroidalyzer). For each eye, a 3D ChT map covering 6 × 6 mm macular region and composed of 12 × 12 grids centered on fovea was generated, and both mean thickness and grid-specific thickness values were calculated. Main Outcome Measures: ChT of each grid, cluster, and macular region; correlation with age, axial length (AL), and sex. Results: The mean ChT was 271.8 ± 56.1 μm, with significant variations across nonmyopia, low, moderate, and high myopia groups ( Conclusions: Using 3D topographic mapping, we provide population-based data on ChT in children, and identified 2 major spatial remodeling patterns: temporal-nasal asymmetry with age and concentric thinning with increasing axial length. These spatially and temporally distinct remodeling patterns likely reflect both physiological growth and myopia-related structural change, supporting the potential role of ChT as a biomarker for myopia development and progression. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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