ArticleOphthalmology science2026
Noncontact Esthesiometer: Large Cohort Study on Agreement with Contact Method and Correlations with Corneal Nerves and Ocular Surface.
Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Purpose: To evaluate the repeatability of noncontact Brill esthesiometer (NBE), its agreement with Cochet-Bonnet esthesiometer (CBE), and the relationship between corneal sensitivity, corneal nerve metrics, and ocular surface parameters. Design: Cross-sectional study. Subjects: This study included 880 eyes, comprising healthy controls (80 eyes), dry eye disease (DED) (170 eyes), neuropathic corneal pain (NCP) (140 eyes), postrefractive surgery (P-RS) (176 eyes), and diabetes mellitus (DM) (314 eyes). Methods: Noncontact Brill esthesiometer and CBE measurements were obtained at central and 4 peripheral corneal quadrants. Both measurements were converted to millinewtons (mN) for analysis. In vivo confocal microscopy for 7 corneal nerve parameters and 4 ocular surface parameters were assessed. Main Outcome Measures: Agreement between NBE and CBE measurements. Correlations between NBE measurements, corneal nerve metrics, and ocular surface characteristics. Results: Noncontact Brill esthesiometer presented excellent intraobserver and interobserver repeatability with both intraclass correlation coefficients >0.980 ( Conclusions: Noncontact Brill esthesiometer and CBE measurements showed good agreement at better corneal sensitivity and are not interchangeable. Noncontact Brill esthesiometer might link better with corneal nerve and ocular surface changes compared with CBE. Financial Disclosures: The author has no/the authors have no proprietary or commercial interest in any materials discussed in this article.
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