CCL signaling drives T Cell-Macrophage crosstalk in the mouse colon during chronic

Erica Silberstein, Spyros Karaiskos, Nikki Tirrell, Charles C Chung, Supriya Kumar, Jung-Sun Cho, Alain Debrabant

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Erica SilbersteinLaboratory of Emerging Pathogens, Office of Blood Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Silver Spring, MD, USA.

Spyros KaraiskosHigh-Performance Virtual Environment (HIVE), Office of Biostatistics and Pharmacovigilance, Center for Biologics and Evaluation, Silver Spring, MD, USA.

Nikki TirrellHigh-Performance Virtual Environment (HIVE), Office of Biostatistics and Pharmacovigilance, Center for Biologics and Evaluation, Silver Spring, MD, USA.

Charles C ChungHigh-Performance Virtual Environment (HIVE), Office of Biostatistics and Pharmacovigilance, Center for Biologics and Evaluation, Silver Spring, MD, USA.

Supriya KumarLaboratory of Emerging Pathogens, Office of Blood Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Silver Spring, MD, USA.

Jung-Sun ChoLaboratory of Emerging Pathogens, Office of Blood Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Silver Spring, MD, USA.

Alain DebrabantLaboratory of Emerging Pathogens, Office of Blood Research and Review, Center for Biologics Evaluation and Review, Food and Drug Administration, Silver Spring, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease, caused by

Indexed as

CCL5-CCR5 axisCD8⁺ cytotoxic T cellschronic digestive Chagas diseasecolonic lamina propria cellsimmune cell communicationmacrophagesscRNA-seqTrypanosoma cruzi

Identifiers

PMID42436983

DOI10.1016/j.isci.2026.116611

PMCPMC13355016

What OpenQuestion holds

Textmetadata

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.