Evidence map›Paper›PMID 42436974›Full record

ArticleiScience2026

A journey through the molecular networks of endomyocardial biopsies to explore ATTR and AL

Raffaello Viganò, Andrea Lomagno, Fredrik Noborn, Jonas Nilsson, Saleh Hamed, Anders Oldfors, Kristjan Karason, Kristina Vukusic, Joakim Sandstedt, Emanuele Bobbio and 4 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Raffaello ViganòDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.
Andrea LomagnoDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.
Fredrik NobornDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Jonas NilssonProteomics Core Facility, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden.
Saleh HamedDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.
Anders OldforsDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Kristjan KarasonDepartment of Cardiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Kristina VukusicDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Joakim SandstedtDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Emanuele BobbioDepartment of Cardiology, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Göran LarsonDepartment of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Sahlgrenska University Hospital, 41345 Gothenburg, Sweden.
Pierluigi MauriDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.
Francesca BrambillaDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.
Dario Di SilvestreDepartment of Biomedical Science, Institute for Biomedical Technologies - National Research Council (ITB-CNR), 20054 Segrate, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoglobulin light chains (AL) and transthyretin (ATTR) characterize most cardiac amyloidosis cases. Several proteomic studies have analyzed microdissected amyloid plaques. However, they did not capture the molecular dysfunctions triggered in surrounding tissue. We, therefore, holistically investigated the protein profiles of endomyocardial biopsies from patients with AL

Indexed as

cardiac amyloidosisendomyocardial biopsynetwork hubsnetwork topologyPPIprotein co-expression networkprotein-protein nteraction net-workproteomics

Identifiers

PMID42436974
PMCPMC13355674

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.