Evidence map›Paper›PMID 42436969›Full record

ArticleGeriatric orthopaedic surgery & rehabilitation2026

Incidence and Related Risk Factors of Pulmonary Complications After Spinal Fusion Surgery: A Retrospective Nationwide Inpatient Sample Database Study.

Yue Wang, Yu-Dong Liao, Yuheng Zhang, Cong-Rui Liao, Jian-Ting Chen

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Article in Geriatric orthopaedic surgery & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yue WangDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0007-8569-5946
Yu-Dong LiaoDivision of Spine Surgery, Department of Orthopaedics, Jiangmen Central Hospital, Jiangmen, Guangdong, China.
Yuheng ZhangDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Cong-Rui LiaoDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jian-Ting ChenDivision of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-6086-0577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postoperative pulmonary complications (PPCs) are common surgical complications and have a significant cost impact. However, the incidence, risk factors, and cost burden of US health care associated with PPCs after spine fusion surgery have not been comprehensively analyzed through large national databases. Methods: A retrospective analysis utilized the Nationwide Inpatient Sample (NIS) database from 2010 to 2019. Adult patients (≥18 years) undergoing spinal fusion were identified via ICD-9-CM/ICD-10-CM procedural codes. PPCs-defined as pneumonia, acute respiratory failure (ARF), pulmonary embolism, or pulmonary edema-were identified by diagnostic codes. Multivariate and stratified logistic regression analyses examined overall and subtype-specific risk factors. Results: Among 812,609 patients, 17,121 (2.11%) developed PPCs, including 9,591 (1.18%) with ARF, 7,376 (0.91%) with pneumonia, 2,159 (0.27%) with pulmonary embolism, and 553 (0.07%) with pulmonary edema. The overall PPCs' rate increased from 2014 to 2019, driven primarily by rising ARF incidence. Patients with PPCs had longer hospital stays (9 vs. 3 days), higher total charges ($197,994 vs. $85,233), and greater in-hospital mortality (5.82% vs. 0.08%, all P < 0.001). Multivariate analysis identified advanced age (≥75: OR = 1.86), multiple comorbidities (OR = 10.98), pulmonary circulation disorders (OR = 11.38), continuous trauma ventilation (OR = 13.34), and septicemia (OR = 14.34) as high-risk factors. Stratified analyses revealed distinct risk profiles: impaired pulmonary reserve and frailty were associated with pneumonia and ARF; venous thromboembolism risk factors with pulmonary embolism; and cardiac, renal, and fluid-related disorders with pulmonary edema. Protective factors included female sex (OR = 0.70), elective admission (OR = 0.32), lumbar fusion (OR = 0.76), and private insurance (OR = 0.89). Conclusion: PPCs after spinal fusion are increasing, primarily due to rising ARF rates. These complications exhibit clinically distinct risk profiles that support subtype-specific assessment and individualized prevention strategies targeting pulmonary reserve, thromboembolic risk, and cardiopulmonary vulnerability.

Indexed as

acute respiratory failurepneumoniapulmonary edemapulmonary embolismrisk factorsspinal fusion

Identifiers

PMID42436969
PMCPMC13354916

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