Evidence map›Paper›PMID 42436958›Full record

ArticleInternational journal of vascular medicine2026

Delayed Cardiovascular Response to Acute Hypotension in Heart Failure Patients Compared to Healthy Adults.

Chelsea N Cady, Soraya M Samii, Cheryl A Blaha, Michael J White, Lawrence I Sinoway, Rachel C Drew

Abstract read
In one paragraph

Article in International journal of vascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chelsea N CadyPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA, pennstatehershey.org.
Soraya M SamiiPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA, pennstatehershey.org.
Cheryl A BlahaPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA, pennstatehershey.org.
Michael J WhiteSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK, birmingham.ac.uk.
Lawrence I SinowayPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA, pennstatehershey.org.
Rachel C DrewPenn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA, pennstatehershey.org.ORCID https://orcid.org/0000-0001-8001-1946

Funding

Penn State Clinical and Translational Science InstituteUL1TR000127 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SINOWAY, LAWRENCE I · 2012 to 2015
$17.1M
The Muscle Reflex: Modes of Engagement and Circulatory ConsequencesP01HL096570 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LEUENBERGER, URS A · 2010 to 2014
$9.9M
NCATS NIH HHS UL1 TR000127NHLBI NIH HHS P01 HL096570
6 · The paper itself

Abstract

Heart failure (HF) patients exhibit autonomic dysfunction. Orthostatic hypotension occurs often in HF and may be linked with altered cardiovascular responsiveness in HF. However, the cardiovascular response to acute hypotension in HF patients compared to healthy adults is unknown. Therefore, data were retrospectively analysed from eight patients with HF with reduced ejection fraction (7 male/1 female) and seven healthy adults (CON; 6 male/1 female) who underwent acute hypotension via thigh cuff deflation following 7.5 min of unilateral lower limb occlusion. Mean arterial blood pressure (MAP; photoplethysmogram) and heart rate (HR; electrocardiogram) were continuously recorded. Statistical analysis involved independent-samples

Indexed as

acute hypotensionblood pressurecardiovascularheart failureheart rate

Identifiers

PMID42436958
PMCPMC13355312

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.