Evidence map›Paper›PMID 42436856›Full record

ArticleMolecular therapy. Advances2026

Engineering inter-promoter spacing in baculovirus dual-expression systems enhances transcription and reduces rAAV2 empty capsids.

Lan Lan, Yuchen Qu, Jie Wang, Wentao Wu, Yao Chen, Weijin Meng, Wangcheng Song, Yongqiang Hou, Lijun Shi, Hao Nan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lan LanCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Yuchen QuCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Jie WangCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Wentao WuCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Yao ChenR&D Department, Xi'an uniBac Biotechnology Co., Ltd., Xi'an 710000, Shaanxi, China.
Weijin MengR&D Department, Xi'an uniBac Biotechnology Co., Ltd., Xi'an 710000, Shaanxi, China.
Wangcheng SongCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Yongqiang HouR&D Department, Shaanxi Bacmid Biotechnology Co., Ltd., Yangling 712100, Shaanxi, China.
Lijun ShiR&D Department, Xi'an uniBac Biotechnology Co., Ltd., Xi'an 710000, Shaanxi, China.
Hao NanCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.
Xiaodong XuCollege of Life Sciences, Northwest A&F University, Yangling 712100, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global delivery of gene therapies demands scalable manufacturing, yet the field is limited by the genome-deficient empty capsids. While the baculovirus expression vector system (BEVS) serves as a leading platform for industrial scale-up, its packaging efficiency is frequently compromised. This failure is largely driven by an imbalanced expression of Rep and Cap proteins. Here, we showed that the conventional back-to-back arrangement of

Indexed as

baculovirus expression vector system BEVSempty capsidpromoterrecombinant adeno-associated virus rAAVtranscription

Identifiers

PMID42436856
PMCPMC13355693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.