ArticleInternational journal of cardiology. Heart & vasculature2026
The PAFIS score for risk stratification of atrial fibrillation detected after stroke: a multicenter cohort study.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Atrial fibrillation after ischemic stroke: What risk scores illuminate and what they miss.International journal of cardiology. Heart & vasculature · 2026Article
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5 authors.
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Abstract
Background: Atrial fibrillation detected after stroke (AFDAS) is clinically important, but AFDAS-specific risk tools for patients without known atrial fibrillation (AF) remain limited. We developed and temporally validated the Prediction of AF in Ischemic Stroke (PAFIS) score. Methods: We retrospectively analyzed ischemic-stroke patients from the National Taiwan University Hospital Integrative Medical Data Center. The development cohort included patients hospitalized in 2010-2020 ( Results: Among KAF-free patients, AFDAS was detected during routine clinical follow-up in 176 of 2175 (8.1%) in the development cohort and 148 of 1366 (10.8%) in the validation cohort. The final PAFIS score included age ≥ 75 years, female sex, valvular heart disease, left atrial diameter ≥ 40 mm, and tricuspid regurgitation peak gradient ≥30 mmHg. AUCs were 0.72 (95% CI, 0.68-0.76) in development and 0.65 (95% CI, 0.60-0.70) in validation. PAFIS outperformed CHA₂DS₂-VASc, HAVOC, and AF-ESUS, but not Brown ESUS-AF. Observed AFDAS detection rates increased across risk groups in both cohorts. Conclusions: PAFIS provides a simple AFDAS-specific tool for selective post-stroke rhythm monitoring. Because AF ascertainment was based on routine clinical care without standardized prolonged monitoring, PAFIS predicts AF detection under routine practice rather than true AFDAS incidence. Prospective multicenter validation with standardized monitoring is warranted.
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