ArticleThe journal of allergy and clinical immunology. Global2026
Immune-stromal dysregulation and senescence in chronic spontaneous urticaria.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic spontaneous urticaria (CSU) involves mast cells and multiple immune pathways, yet mechanisms sustaining disease chronicity remain incompletely defined. Objective: We sought to delineate immune, stromal, and senescence-associated transcriptional programs in CSU lesional skin. Methods: Lesional biopsy samples from 28 adults with CSU and 22 matched healthy controls were analyzed by bulk RNA sequencing, guided topic model-based deconvolution, and p16INK4a immunohistochemistry. Differential expression, gene set enrichment, and immune module scoring were performed. Results: CSU skin showed 449 differentially expressed genes (309 up, 140 down), including Conclusions: Adult CSU lesions comprise a chronically inflamed immune-stromal niche, integrating T-cell activation, structural cell reprogramming, and cellular senescence. These data extend current models of CSU and identify senescence as a potential amplifier of inflammation and a testable target for future mechanistic and interventional studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.