ArticleJournal of oral biology and craniofacial research
Development and characterisation of copper oxide nanoparticle-functionalized corn husk cellulose-PVA membranes for guided tissue regeneration.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Guided tissue regeneration (GTR) membranes enable selective cell repopulation, but many existing membranes suffer from limited mechanical stability, rapid degradation, and a lack of sustainable biomaterials. Corn husk, an agricultural waste rich in cellulose, offers an eco-friendly alternative. Polyvinyl alcohol (PVA) reinforcement and copper oxide nanoparticles (CuO NPs) may further enhance strength and biological performance. This study fabricated and in vitro evaluated an electrospun GTR membrane combining corn husk-derived cellulose, PVA, and CuO NPs. Materials and methods: Cellulose was extracted from corn husk through glycerine treatment, alkaline purification, and peroxide bleaching. CuO nanoparticles were synthesised by precipitating Cu(OH) Results: SEM and EDS confirmed uniform CuO nanoparticle dispersion within the PVA/Cellulose fibres; FTIR verified chemical integration. MTT assay showed >96% cell viability, with small but significant reductions at 1:1 and 1:2 dilutions (p < 0.01). The membrane exhibited hydrophilicity (contact angle ∼19°), tensile stress of 0.43 MPa, and strong antibacterial effects against Conclusion: The composite membrane demonstrated excellent biocompatibility, antimicrobial activity, and osteogenic potential, supporting its promise as a sustainable GTR material.
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