Evidence map›Paper›PMID 42436667›Full record

ArticleClinical Medicine Insights. Cardiology2026

Longitudinal Analysis of Heparin-Binding Protein (HBP) and Serum Amyloid a Protein (SAA) Versus Interleukin 6 (IL-6), C-Reactive Protein (CRP), and Procalcitonin (PCT) During Both the Acute Postoperative Period and Recovery at Three Months From Non-emergent Cardiac Surgery.

Krzysztof Laudanski, Ahmed Sayed Ahmed, Mohamed A Mahmoud, Hossam Gad, Benjamin R E Harris, Ryan Smith, Dandan Zhu, Abdelhamed Elgazar, Anil Vasishta, Gajic Ognjen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical Medicine Insights. Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Krzysztof LaudanskiDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0000-0002-7373-0851
Ahmed Sayed AhmedDivision of Pulmonary Care and Critical Care, Mayo Clinic, Rochester, MN, USA.
Mohamed A MahmoudDivision of Pulmonary Care and Critical Care, Mayo Clinic, Rochester, MN, USA.
Hossam GadDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.ORCID https://orcid.org/0009-0001-1828-8167
Benjamin R E HarrisDivision of Pulmonary Care and Critical Care, Mayo Clinic, Rochester, MN, USA.
Ryan SmithDivision of Pulmonary Care and Critical Care, Mayo Clinic, Rochester, MN, USA.
Dandan ZhuDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.
Abdelhamed ElgazarDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.
Anil VasishtaAshyana Consulting, Dundee, Scotland, UK.
Gajic OgnjenDivision of Pulmonary Care and Critical Care, Mayo Clinic, Rochester, MN, USA.
Daniel A DiedrichDepartment of Anesthesiology and Perioperative Care, Mayo Clinic, Rochester, MN, USA.
Juan CrestanelloDivision of Cardiac Surgery, Mayo Clinic, Rochester, MN, USA.

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI VAN DEERLIN, VIVIANNA M · 1991 to 2020
$35.1M
Epigenetic mediated long-term aberrations in myeloid cells after critical illnessK23GM120630 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI LAUDANSKI, KRZYSZTOF · 2017 to 2020
$783k
NIA NIH HHS P30 AG010124NIGMS NIH HHS K23 GM120630
6 · The paper itself

Abstract

Variability in novel inflammatory markers (HBP and SAA) post-surgery could indicate ongoing perioperative inflammation. This pilot cohort study collected blood from 99 patients undergoing elective cardiac surgery at baseline, 24 hours, 7 days, and 3 months post-surgery. Inflammatory markers (HBP, SAA, PCT, CRP, IL-6) were measured with a point-of-care device. Demographic and clinical data were extracted from health records. Serum SAA increased significantly in the acute postoperative phase (M

Indexed as

cardiac surgeryC-reactive proteinheparin-binding proteininflammationinterleukin 6serum amyloid a protein

Identifiers

PMID42436667
PMCPMC13354903

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.