ArticleBiomaterial investigations in dentistry2026
Short-term histopathological effects of direct peripheral nerve exposure to AH Plus® Bioceramic Sealer in rats: an exploratory assessment of Stemregen® supplementation.
Article in Biomaterial investigations in dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Extrusion of root canal sealers into neurovascular tissues can result in rare but serious neurological complications, including paresthesia and neuropathic pain. This study aimed to evaluate the histopathological effects of direct peripheral nerve exposure to AH Plus® Bioceramic Sealer and to assess the influence of Stemregen® supplementation on histopathological tissue responses. Materials and methods: Forty-eight male Sprague-Dawley rats were randomly assigned to four groups ( Results: Severe axonal degeneration, inflammation, and fibrosis were observed in the Bioceramic group compared to controls ( Conclusions: These findings indicate that direct exposure to a bioceramic root canal sealer is associated with histopathological alterations in peripheral nerve tissue, whereas systemic administration of Stemregen® was associated with lower injury scores without achieving statistical significance.
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