ArticleAmerican journal of industrial medicine2026
The Risk of Cardiovascular Diseases for Shift Workers in the Prospective Heinz Nixdorf Recall Study.
Article in American journal of industrial medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundShift work can disrupt circadian rhythms and is postulated to play a role in cardiovascular diseases (CVD). In the German prospective population-based Heinz Nixdorf Recall Study, we analyzed longitudinal associations between shift work and night-shift work with CVD.
methodsCVD was defined as a fatal or non-fatal cardiac or cerebrovascular event or interventional coronary revascularization during an average follow-up of 15 years. Retrospective shift-work information was assessed as binary and as lifetime duration in years. Adjusted log-linear Poisson regression models were applied to estimate incidence rate ratios (IRR) and 95% confidence intervals (CI) for the effect of shift and night-shift work on incident events. Stratified analyses by sex, diurnal preference, and blue-collar status were also performed.
resultsIncident CVD was not associated with shift work (N = 3024; shift work for at least 1 year: IRR = 0.87, 95% CI = 0.68-1.10; night-shift work for at least 1 year: IRR = 0.87, 95% CI = 0.66-1.14). However, we observed sex differences with reduced incidence of CVD for long duration of night-shift work among men (N = 1369 with 380 night-shift workers; model for duration of night-shift work: 1- < 10 years: IRR = 1.08, 95% CI = 0.74-1.57; 10+ years: IRR = 0.64, 95% CI = 0.42-0.96). For women, we found slightly elevated IRRs (N = 1438 with 91 night-shift workers; model for duration of night-shift work: 1- < 10 years: IRR = 1.11, 95% CI = 0.35-3.50; 10+ years: IRR = 2.05, 95% CI = 0.75-5.61). These estimates were stronger in women that never worked in blue-collar jobs (10+ years night-shift work: IRR = 3.22, 95% CI = 1.17-8.92).
conclusionsWe did not observe consistently increased risks of CVD with shift and night workers. However, stratified analyses pointed toward sex- and job-specific vulnerable subgroups.
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