ArticleSleep2026
Cross-sectional and longitudinal relationships between multi-dimensional sleep composites and cognition in multi-ethnic study of atherosclerosis.
Caitlin Paquet, Ethan I Powell, Jarvis T Chen, Nataliia Kozhemiako, Kaitlin S Potts, Cecilia Castro-Diehl, Tamar Sofer, Suzanne M Bertisch, Wendy Post, Timothy Hughes and 2 more
Abstract read
In one paragraphArticle in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Caitlin PaquetDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-2019-3500 Ethan I PowellDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Jarvis T ChenSocial and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, MA, United States.
Nataliia KozhemiakoDivision of Sleep and Circadian Disorders, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Kaitlin S PottsDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-7778-4884 Cecilia Castro-DiehlDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Tamar SoferDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States.ORCID 0000-0001-8520-8860 Suzanne M BertischDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Wendy PostDepartment of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, United States.
Timothy HughesSchool of Medicine, Wake Forest University, Winston-Salem, NC, United States.
Shaun PurcellDivision of Sleep and Circadian Disorders, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-7402-5812 Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0002-6585-1610 Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MSUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6MLongitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and SusceptibilityR01AG070867 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI PURCELL, SHAUN M, REDLINE, SUSAN S. · 2021 to 2024
$9.9MASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95160 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL · 2007 to 2015
$7.7MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC95164 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG · 2007 to 2015
$7.0MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95161 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI SHEA, STEVEN · 2007 to 2014
$6.4MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95165 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BURKE, GREGORY L · 2007 to 2014
$6.3MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95163 · NHLBI · UNIVERSITY OF MINNESOTA · PI FOLSOM, AARON R · 2007 to 2014
$6.1MTITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)N01HC95162 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI POST, WENDY · 2007 to 2015
$6.0MMulti-Ethnic Study of Atherosclerosis (MESA) Sleep Ancillary studies NIH-NHLBI R01HL098433Multi-Ethnic Study of Atherosclerosis (MESA) Sleep Ancillary studies NIH-NIA 5R01AG070867NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI UL1TR000040NHLBI UL1TR001079NHLBI UL1TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS R01 HL098433NIA NIH HHS R01 AG070867
6 · The paper itselfAbstract
STUDY
objectivesSleep is critical for maintaining overall brain health and may influence the trajectory of cognitive impairment. Using a multidimensional conceptualization of sleep, we hypothesized that data-derived multidimensional sleep composites would be associated with cognitive performance.
methodsData from four examinations (2010-2024) in the Multi-Ethnic Study of Atherosclerosis were used to examine cross-sectional and longitudinal associations between multimodal sleep and cognition. Multidimensional sleep composites were derived from 39 objective and subjective sleep variables using principal components analysis. Cognition was measured using a global cognition composite (GCC), a standardization of total scores across Digit Symbol Coding, Digit Span, and Cognitive Abilities Screening Instrument. Linear regression analyzed cross-sectional associations between sleep composites and cognition, and linear mixed-effects models examined associations with within-person cognitive change over time.
resultsIn cross-sectional analyses of 1628 participants (mean age 68.0; 54.9% female), 13 sleep composites explained about 71% of the sample's variance. After adjusting for demographic and lifestyle factors, five sleep composites were associated with GCC cross-sectionally: (1) electroencephalography (EEG) power spectral density [ß (per standard deviation) = 0.065; 95% CI 0.03-0.10], (2) actigraphy based sleep continuity (ß = 0.049; 0.01-0.08), (3) spindle density (ß = 0.052; 0.02-0.09), (4) spindle-slow oscillation coupling (ß = 0.050; 0.01-0.09), and (5) rapid eye movement sleep (ß = 0.047; 95% CI 0.01-0.08). In the longitudinal analysis, actigraphy based sleep continuity and variability were associated with cognitive decline, although significance decreased after multiple comparison adjustment.
conclusionsEEG-based sleep microstructure and actigraphy-based sleep continuity were associated with cognitive performance cross-sectionally, while actigraphy-based sleep continuity was associated with cognition longitudinally. These findings support a multidimensional framework for understanding sleep-related risk factors for cognitive decline.
Indexed as
AtherosclerosisCognitionSleepAgedCross-Sectional StudiesElectroencephalographyEthnicityFemaleHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsSleep Durationactigraphycognitionmulti-dimensionalPCAsleep health
Identifiers
PMID42436643
PMCPMC13658260
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