ArticlePhysiological reports2026
Acute hypoxia impairs uphill running performance and alters metabolic responses in adult trained trail runners: A pilot study.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To investigate the effects of acute hypoxia on uphill running and physiological responses during a 12-min uphill time trial in trained trail runners and to assess potential sex differences. Thirteen trained trail runners (six females) completed a 12-min treadmill uphill time trial (+12% incline) in normoxia and simulated hypoxia (~2500 m). Performance, physiological, and perceptual responses were recorded. Hypoxia reduced distance covered (-15%), speed (-15%), and power output (-8.5%) (all p < 0.001), while increasing respiratory exchange ratio and blood lactate concentration. Relative performance decrements were similar between sexes. Acute hypoxia impairs uphill running performance and increases metabolic strain irrespective of sex.
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