Evidence map›Paper›PMID 42436541›Full record

ArticleActa neuropathologica communications2026

Repeated mild spinal cord contusions exacerbate tauopathy development in PS19 mice.

Nicolas Halloin, Nicolas Debortoli, Lidia Lopez-Gutiérrez, Hélène Collignon, Zoé Marlier, Kunie Ando, Valérie Suain, Louise Conrard, Margaux Mignolet, Lindsay Sprimont and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicolas HalloinURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Nicolas DebortoliNamur Molecular Tech, NARILIS, CHU UCL Namur, Yvoir, Belgium.
Lidia Lopez-GutiérrezAlzheimer and Other Tauopathies Research Group, Medical Faculty, ULB Center for Diabetes Research, ULB Neuroscience Institute, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium.
Hélène CollignonURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Zoé MarlierURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Kunie AndoAlzheimer and Other Tauopathies Research Group, Medical Faculty, ULB Center for Diabetes Research, ULB Neuroscience Institute, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium.
Valérie SuainCenter for Microscopy and Molecular Imaging, ULB, Gosselies, Belgium.
Louise ConrardCenter for Microscopy and Molecular Imaging, ULB, Gosselies, Belgium.
Margaux MignoletURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Lindsay SprimontURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium.
Marino CarusoLaboratory for Disease Mechanisms in Cancer, KU Leuven, Leuven, Belgium.
Aurélie LadangDepartment of Clinical Chemistry, CHU Liège, Liège, Belgium.
Jonathan DegosserieNamur Molecular Tech, NARILIS, CHU UCL Namur, Yvoir, Belgium.
Karelle LeroyAlzheimer and Other Tauopathies Research Group, Medical Faculty, ULB Center for Diabetes Research, ULB Neuroscience Institute, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium.
Charles NicaiseURPhyM, NARILIS, University of Namur, Rue de Bruxelles 61, 5000, Namur, Belgium. charles.nicaise@unamur.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Growing evidence indicates that traumatic brain injury constitutes a significant risk factor for the development of age-related tauopathies, yet the consequences of repeated mild spinal cord injuries (rmSCI) remain insufficiently explored. In this context, we developed a mouse model undergoing two successive mild cervical contusions during young adulthood, which do not produce immediate functional motor deficits, thereby mimicking real-life conditions of occupational- or sports-related trauma. rmSCI were induced in PS19 (hTau

Indexed as

Spinal Cord InjuriesTauopathiesAnimalsBrainDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLMice, TransgenicPhosphorylationSpinal Cordtau Proteinstau ProteinsRepeated mildSpinal cord injuryTauopathyType 1 interferon

Identifiers

PMID42436541
PMCPMC13640360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.