ArticleBMC veterinary research2026
First report and molecular characterization of gizzard erosion-associated fowl adenovirus serotype 8a in Thailand.
Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGizzard erosion (GE) and ulceration are occasionally have been occasionally associated with several serotypes of fowl adenovirus (FAdV), particularly serotype 1 (FAdV-1). Clinical signs of adenoviral GE (AGE) are often subclinical with low mortality. In Thailand, FAdV-2, 8b, and 11 have been reported in association with inclusion body hepatitis (IBH), however, AGE remains undocumented. Therefore, this study aimed to investigate FAdV-associated GE and characterize the FAdV strain detected in GE-affected chickens in Thailand.
resultsHistopathological evaluation revealed intranuclear inclusion bodies within glandular epithelial cells of eroded gizzards. In situ hybridization (ISH) demonstrated positive signals for FAdV nucleic acid within affected glandular epithelial cells, and PCR targeting the hexon gene further confirmed the presence of FAdV genetic material. Sequencing and phylogenetic analyses of the complete hexon and fiber genes identified the virus associated with GE as FAdV-8a, designated FAdV8a_NPT_KU001_25. Multiple amino acid sequence alignment of the Fiber protein showed that the Thai GE-associated isolate was more closely related to a gizzard-tropic FAdV-8a strain than to an IBH-associated FAdV-8a strain. Although amino acid variations within the knob domain may be associated with differences in tissue tropism and clinical manifestations, their biological significance and role in pathogenesis require further investigation.
conclusionsThis study represents the first report of a potential GE-associated FAdV-8a strain in Thailand. The findings suggest an association between FAdV-8a infection and GE lesions in affected chickens. However, the etiological role and pathogenic mechanisms of FAdV-8a in GE remain unclear and require further investigation, including experimental reproduction studies. The genomic characterization of this strain provides additional information that may contribute to a better understanding of the genetic diversity and evolution of FAdV-8a.
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