Evidence map›Paper›PMID 42436485›Full record

ArticleJournal of nanobiotechnology2026

A novel pH-responsive nanoreactor for pyroptosis induction: multifaceted ROS amplification drives potent immunotherapy against triple-negative breast cancer.

Wenjia Liu, Ying Wang, Xiangyu Hao, Yangxun Wang, Xiaofan Zhang, Jinchao Zhang, Kun Ge, Guoqiang Zhou

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenjia LiuCollege of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Ying WangCollege of Basic Medical Science, Hebei University, Baoding, 071002, China.
Xiangyu HaoCollege of Basic Medical Science, Hebei University, Baoding, 071002, China.
Yangxun WangCollege of Basic Medical Science, Hebei University, Baoding, 071002, China.
Xiaofan ZhangCollege of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Jinchao ZhangCollege of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China.
Kun GeCollege of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China. gekun@hbu.edu.cn.
Guoqiang ZhouCollege of Chemistry and Materials Science, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, State Key Laboratory of New Pharmaceutical Preparations and Excipients, Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding, 071002, China. zhougq@hbu.edu.cn.

Funding

Natural Science Foundation of Hebei Province B2023201108Science Fund for Distinguished Young Scholars of Hebei Province B2021201045
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is associated with rapid progression and poor sensitivity to monotherapies, necessitating combination strategies to enhance tumor immunogenicity, reprogram the tumor microenvironment (TME), and convert immunologically "cold" tumors into "hot" ones. In this study, we develop a pH-responsive, pyroptosis-inducing nanoreactor, ZnS/ZIF-90:Fe/Vk3 (ZZFV), designed to elicit potent antitumor immunity. Under acidic conditions, ZZFV rapidly degrades, releasing Zn

Indexed as

Antineoplastic AgentsImmunotherapyPyroptosisReactive Oxygen SpeciesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorFemaleHumansHydrogen-Ion ConcentrationImidazolesMiceTumor MicroenvironmentZeolitesAntineoplastic AgentsImidazolesReactive Oxygen SpeciesZeolitesImmunotherapyLung metastasispH-ResponsivePyroptosisTriple-negative breast cancer

Identifiers

PMID42436485
PMCPMC13640175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.