Evidence map›Paper›PMID 42436388›Full record

ArticleBMC immunology2026

IL-37a facilitates allergen immunotherapy in a house dust mite-induced mouse model of allergic asthma.

Zheng Jin, Xiaopeng Jing, Ji Zeng, Zhenhua Zhu

Abstract read
In one paragraph

Article in BMC immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zheng JinDepartment of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, China.
Xiaopeng JingDepartment of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, China.
Ji ZengDepartment of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, China. whzjmicro@163.com.
Zhenhua ZhuHubei Provincial Clinical Research Center for Orthopaedics, Wuhan, China. zhuzhenhua93@hotmail.com.

Funding

Hubei Natural Science Foundation 2024AFB479Hubei Natural Science Foundation 2024AFB482Wuhan 2023 Medical Research Project WX23Q17Wuhan Natural Science Foundation Exploration Plan 2024040801020374Wuhan Natural Science Foundation Exploration Plan 2025020701020268
6 · The paper itself

Abstract

In recent years, the incidence of allergic asthma has increased dramatically. Allergen immunotherapy (AIT) is an effective approach to achieve long-term remission of allergic asthma and has gained widespread attention. However, current AIT suffers from low efficacy and long treatment duration. In this study, we found that IL-37a transgenic mice with allergic asthma exhibited reduced pulmonary inflammation, decreased Th2 cytokines, and lower allergen-specific IgE following AIT. Mechanistic studies revealed increased IL-37

Indexed as

AsthmaDesensitization, ImmunologicInterleukin-1PyroglyphidaeAllergensAnimalsAntigens, DermatophagoidesCytokinesDisease Models, AnimalHumansImmunoglobulin EMiceMice, TransgenicTh2 CellsAllergensAntigens, DermatophagoidesCytokinesImmunoglobulin EInterleukin-1Allergen immunotherapyAllergic asthmaBregsIL-37a

Identifiers

PMID42436388
PMCPMC13670632

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.