Structural basis of Mlc-mediated transcriptional regulation of carbohydrate metabolism.

Patrick Roth, Inken Fender, Jean-Marc Jeckelmann, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patrick RothInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0009-0005-4458-3193

Inken FenderInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0009-0000-1230-0260

Jean-Marc JeckelmannInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-9973-2700

Zöhre UcurumInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland.

Thomas LemminInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0001-5705-4964

Dimitrios FotiadisInstitute of Biochemistry and Molecular Medicine, Medical Faculty, University of Bern, Bern, Switzerland. dimitrios.fotiadis@unibe.ch.ORCID http://orcid.org/0000-0001-9682-7931

Funding

Novartis Stiftung für Medizinisch-Biologische Forschung (Novartis Foundation for Medical-Biological Research) #24A045Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 10001444Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 194606UniBern Forschungsstiftung (Bern University Research Foundation) 8/2023Universität Bern (University of Bern) N/A

6 · The paper itself

Abstract

The global transcriptional repressor Mlc of Escherichia coli regulates genes involved in carbohydrate transport and metabolism, particularly glucose uptake via the glucose-specific phosphotransferase system (PTS). Unlike conventional repressors, Mlc exemplifies a system in which interactions with diverse macromolecules govern its activity. Here, we present cryo-electron microscopy structures of Mlc alone and in complexes with regulatory partners, including the glucose-specific PTS transporter IICB

Indexed as

Carbohydrate MetabolismEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialRepressor ProteinsCryoelectron MicroscopyGlucoseMolecular Dynamics SimulationPhosphoenolpyruvate Sugar Phosphotransferase SystemProtein BindingTranscription, GeneticEscherichia coli ProteinsGlucosePhosphoenolpyruvate Sugar Phosphotransferase SystemRepressor Proteins

Identifiers

PMID42436118

DOI10.1038/s41467-026-75270-8

PMCPMC13482132

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.