Evidence map›Paper›PMID 42435651›Full record

ArticleRedox biology2026

Endothelial cytochrome P450 -derived cholesterol limits angiogenesis.

Pedro F Malacarne, Melina Lopez, Souradeep Chatterjee, Niklas Herrle, Lisa Weiss, Stefan Günther, Timothy Osborne, Clemens Glaubitz, Tobias Schmid, Nina Kurrle and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pedro F MalacarneGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Melina LopezGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Souradeep ChatterjeeGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Niklas HerrleGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Lisa WeissGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Stefan GüntherMax-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Timothy OsborneJohns Hopkins University School of Medicine, Division of Endocrinology, Diabetes and Metabolism, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital, Saint Petersburg, USA.
Clemens GlaubitzGoethe University Frankfurt, Institute for Biophysical Chemistry, Frankfurt am Main, Germany.
Tobias SchmidGoethe University Frankfurt, Institute of Biochemistry I, Frankfurt am Main, Germany.
Nina KurrleGoethe University Frankfurt, University Medicine Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Frankfurt Cancer Institute, Goethe-University Frankfurt, Frankfurt/Main, 60596, Germany.
Frank SchnütgenGoethe University Frankfurt, University Medicine Frankfurt, Department of Medicine, Hematology/Oncology, Frankfurt am Main, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, and German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany; Frankfurt Cancer Institute, Goethe-University Frankfurt, Frankfurt/Main, 60596, Germany.
Dieter LütjohannUniversity of Bonn, Institute for Clinical Chemistry and Clinical Pharmacology, Bonn, Germany.
Ralf P BrandesGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany.
Flávia RezendeGoethe University, Institute for Cardiovascular Physiology, Frankfurt am Main, Germany; German Centre of Cardiovascular Research (DZHK), Partner Site Rhein Main, Germany. Electronic address: rezende@vrc.uni-frankfurt.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cytochrome P450 redox system is composed of a cytochrome P450 reductase (POR) and multiple CYP450 enzymes (CYP450). Of the CYP450 isoenzymes, CYP51A1 is essential for endogenous cholesterol biosynthesis. Elevated circulating cholesterol is a well-established risk factor for cardiovascular disease, however, the role of intracellular cholesterol synthesis in normal endothelial function remains unclear. To investigate this, we generated CRISPR/Cas9 knockouts of the cytochrome P450 reductase in primary human endothelial cells (EC) and studied an endothelial-specific, tamoxifen-inducible POR knockout mouse (ecPOR

Indexed as

AngiogenesisCholesterolCytochrome P-450 Enzyme SystemEndothelial CellsSterol 14-DemethylaseAnimalsHumansMiceMice, KnockoutProto-Oncogene Proteins c-aktSignal TransductionSterol Regulatory Element Binding Protein 2CholesterolCYP51A1 protein, humanCytochrome P-450 Enzyme SystemProto-Oncogene Proteins c-aktSterol 14-DemethylaseSterol Regulatory Element Binding Protein 2AngiogenesisCholesterolCytochrome P450 oxidoreductaseSREBP2

Identifiers

PMID42435651
PMCPMC13376976

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.