Evidence map›Paper›PMID 42435416›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Abnormal activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron contributes to fructose-induced salt-sensitive hypertension.

Ronghao Zhang, Najeong Kim, Shujie Shi, Darshan Aatmaram Jadhav, Autumn Brostek, Beau R Forester, Rashi Shukla, Christina Qu, Benjamin K Kramer, Fraser J Moss and 3 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ronghao ZhangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0001-6418-090X
Najeong KimDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0009-0000-5910-8620
Shujie ShiDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-3785-853X
Darshan Aatmaram JadhavDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0009-0001-0997-5491
Autumn BrostekDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0001-6646-3364
Beau R ForesterDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0001-7517-4636
Rashi ShuklaDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Christina QuDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0009-0005-7259-1385
Benjamin K KramerDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0009-0008-0514-4173
Fraser J MossDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0002-8519-6991
Jeffrey L GarvinDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0002-8647-3815
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-2413-5415
Agustin Gonzalez-VicenteDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.ORCID 0000-0002-3682-0815

Funding

Mechanisms of tubular atrophy in renal diseaseR01DK067528 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI SCHELLING, JEFFREY R · 2005 to 2025
$7.1M
The Role of The Proximal Nephron In Salt-Sensitive HypertensionR01HL128053 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GARVIN, JEFFREY L. · 2016 to 2024
$4.3M
Role of PON3 in regulating renal Na+ and K+ homeostasisR01DK130901 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2021 to 2025
$1.6M
Using transcriptomics and ex vivo organotypic models to discover mechanisms of APOL1-associated podocytopathiesK01DK128304 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Agustin Gonzalez-Vicente · 2023 to 2026
$524k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL128053HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK128304HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK130901NHLBI NIH HHS R01 HL128053NIDDK NIH HHS K01 DK128304NIDDK NIH HHS R01 DK067528NIDDK NIH HHS R01 DK130901
6 · The paper itself

Abstract

Fructose high-salt (FHS) diets increase blood pressure (BP). The mineralocorticoid receptor (MR) regulates Na

Indexed as

AldosteroneBlood PressureFructoseHypertensionNephronsReceptors, MineralocorticoidSodium Chloride, DietaryAnimalsDisease Models, AnimalEpithelial Sodium ChannelsMaleMiceMice, Inbred C57BLRatsRats, Sprague-DawleyAldosteroneEpithelial Sodium ChannelsFructoseReceptors, MineralocorticoidSodium Chloride, Dietaryaldosteronedistal nephronglucocorticoidsmineralocorticoidssalt-sensitive hypertension

Identifiers

PMID42435416
PMCPMC13463287

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.