HIV and Syphilis Seroprevalence and Correlates of HIV-Syphilis Co-infection Among Black and Latina Women of Transgender Experience and Transfeminine People in Los Angeles County, 2023-2024.

Yingbo Ma, Gia Olaes, Angela Cristobal, Benny Deng, Siri Chirumamilla, Ekow Kwa Sey

Abstract read

In one paragraph

Article in AIDS and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yingbo MaDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA. yma@ph.lacounty.gov.ORCID http://orcid.org/0000-0001-7898-6533

Gia OlaesDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA.

Angela CristobalDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA.

Benny DengDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA.

Siri ChirumamillaDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA.

Ekow Kwa SeyDivision of HIV and STD Programs, Los Angeles County Department of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6373-8358

Funding

Los Angeles County Department of Public Health Local fundNational Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention 5NU62PS924771

6 · The paper itself

Abstract

Women of transgender experience and transfeminine people (WTE/TFP) are disproportionately impacted by HIV, yet local data on syphilis seroprevalence and HIV-syphilis co-infection among Black and Latina WTE/TFP in Los Angeles County (LAC) remain limited. This study examined HIV and treponemal syphilis seroprevalence and identified correlates of HIV-syphilis co-infection among Black and Latina WTE/TFP in LAC. From August 2023 through June 2024, the National HIV Behavioral Surveillance (NHBS) in LAC recruited WTE/TFP using respondent-driven sampling. Among 352 non-Hispanic Black (n = 99) and Latina (n = 253) participants with valid HIV and treponemal syphilis test results, HIV seroprevalence was 42%, treponemal syphilis seroprevalence was 56%, and HIV-syphilis co-infection was 33%, indicating substantial overlap of the two epidemics. Structural vulnerability was widespread, including food insecurity (70%), incarceration history (46%), homelessness (39%), and unemployment (39%). Co-infection was unevenly distributed. In adjusted analysis, Black participants had a 70% higher prevalence of co-infection than Latina participants (aPR = 1.70, 95% CI 1.14-2.52), and methamphetamine use was associated with nearly twice the prevalence of co-infection (aPR = 1.89, 95% CI 1.22-2.94). Continued efforts to expand routine syphilis screening, timely staging and treatment, doxycycline post-exposure prophylaxis education and counseling, and integrated harm reduction services are vital to addressing this overlapping epidemic. These findings also support sustained investment in Black-centered, peer-led trans community organizations and trans-competent clinical care to better address the co-occurring HIV and syphilis burden among Black and Latina WTE/TFP in LAC.

Indexed as

Black or African AmericanCoinfectionHispanic or LatinoHIV InfectionsSyphilisTransgender PersonsAdolescentAdultFemaleHIV SeroprevalenceHumansLos AngelesMaleMiddle AgedSeroepidemiologic StudiesYoung AdultHIV and STI co-infectionRacial health inequitiesSyphilisWomen of transgender experience and transfeminine people

Identifiers

PMID42435279

DOI10.1089/trgh.2019.0008

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