Evidence map›Paper›PMID 42435217›Full record

ArticleCellular and molecular life sciences : CMLS2026

APOC1⁺IFI30⁺ TAMs orchestrate colorectal cancer liver metastasis by coupling cholesterol biosynthesis with secretion of immunosuppressive factors.

Zheyou Cai, Yibing Chen, Lei Cui, Jine Yao, Jianghua Qiao, Weihong Sun, Haisheng Liu, Linhao Yang, Zhuang Yang, Quentin Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zheyou Cai *Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Yibing Chen *Genetic and Prenatal Diagnosis Center, Department of Gynecology and Obstetrics, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Lei Cui *Yuebei People's Hospital Affiliated to Shantou University Medical College, Shaoguan, China.
Jine YaoDepartment of Oncology, The People's Hospital of JiangMen, Jiangmen, China.
Jianghua QiaoDepartment of Breast Disease, Henan Breast Cancer Centre, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Weihong SunMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China.
Haisheng LiuMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China.
Linhao YangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China.
Zhuang YangMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China.
Quentin LiuState Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.
Benxin HouDepartment of General Surgery, The Third People's Hospital of Hainan Province, Sanya, China. Xjhbxt@163.com.
Zhengzhi ZouMOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering, South China Normal University, Guangzhou, China. zouzhengzhi@m.scnu.edu.cn.ORCID http://orcid.org/0000-0002-1893-7649
Dongming LaiShenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei, China. laidm@mail.sysu.edu.cn.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 81972479Innovative Research Group Project of the National Natural Science Foundation of China U2004118Jiangmen People's Hospital Dean's Research Fund JRYYZYJJJ2025A01Medical Science and Technology Research Project of Henan Province SBGJ202502040Natural Science Foundation of Guangdong Province 2024A1515010310Natural Science Foundation of Henan Province 202300410359Sanya Municipal talent development special fund project 2023-14the Research and Innovation Team Fund of the First Affiliated Hospital of Zhengzhou University QNCXTD2023019
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) play a crucial role in colorectal cancer (CRC) metastasis, particularly in the establishment of the liver metastatic niche. TAMs facilitate metastasis by enabling epithelial-mesenchymal transition (EMT) and suppressing anti-tumor immunity. While their roles in primary tumors have been extensively investigated, their functions at metastatic sites remain poorly understood. In this study, we analyzed the single-cell RNA sequencing data from 46 CRC patients, encompassing 402,972 cells, to identify macrophage subsets associated with liver metastasis. A distinct population of APOC1

Indexed as

Apolipoprotein C-ICholesterolColorectal NeoplasmsLiver NeoplasmsTumor-Associated MacrophagesCell Line, TumorEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHumansTumor MicroenvironmentApolipoprotein C-ICholesterolAPOC1Colorectal cancerIFI30Metastatic colonizationTumor-associated macrophages

Identifiers

PMID42435217
PMCPMC13646245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.