Evidence map›Paper›PMID 42435204›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

PET molecular imaging of in vivo brain metabolism, synaptic density and glial reactivity changes after neural stem cell transplantation on a rat model of ischemic stroke.

Peili Cen, Xiaoyun Luo, Yan Zhong, Lu Hong, Chentao Jin, Hang Zhang, Linghan Wu, Ziyun Fang, Jia Liu, Mei Tian and 2 more

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Peili Cen *Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Hangzhou, 310022, China.ORCID http://orcid.org/0000-0003-1497-2209
Xiaoyun Luo *Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Yan Zhong *Department of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Hangzhou, 310022, China.
Lu HongInstitute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Chentao JinDepartment of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Hangzhou, 310022, China.
Hang ZhangInstitute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Linghan WuInstitute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Ziyun FangInstitute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Jia LiuInstitute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, 310009, China.
Mei TianHuman Phenome Institute, Fudan University, Shanghai, 201203, China. tianmei@fudan.edu.cn.
Hong ZhangDepartment of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Hangzhou, 310022, China. hzhang21@zju.edu.cn.ORCID http://orcid.org/0000-0002-4084-5150
Jing WangDepartment of Nuclear Medicine, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Hangzhou, 310022, China. wangjing5678@zju.edu.cn.

Funding

Fundamental Research Funds for the Central Universities 226-2025-00035National Key Research and Development Program of China 2021YFA1101700National Natural Science Foundation of China 82302267National Natural Science Foundation of China 82361148130National Natural Science Foundation of China 82394433Priority-Funded Postdoctoral Research Project, Zhejiang Province ZJ2025077
6 · The paper itself

Abstract

purposeThe in vivo processes underlying neural stem cell (NSC) transplantation for ischemic stroke remain unclear, primarily due to the lack of effective in vivo monitoring and evaluation approaches. Therefore, we systematically investigated the in vivo mechanisms of NSC transplantation by positron emission tomography (PET) on a rat model with ischemic stroke.

methodsNSCs were generated from human induced pluripotent stem cells (hiPSCs), and their neuronal differentiation potential was assessed in vitro. After transplantation into rats with photothrombotic stroke, neurological function was evaluated using the cylinder test and forelimb placing test.

resultsNSCs derived from hiPSCs exhibited high neuronal differentiation potential in vitro. After NSC transplantation, neurological function of rats with ischemic stroke was recovered, while transplanted NSCs differentiated into neurons and established synaptic connections in the rat brain. In vivo brain metabolism and synaptic density were both restored, revealed by

conclusionOur findings suggest PET molecular imaging can systematically monitor the brain metabolism, synaptic density and glial reactivity, providing effective in vivo monitoring and evaluation approaches for NSC transplantation in ischemic stroke.

Indexed as

BrainIschemic StrokeNeural Stem CellsNeurogliaPositron-Emission TomographyStem Cell TransplantationSynapsesAnimalsBrain IschemiaCell DifferentiationDisease Models, AnimalFluorodeoxyglucose F18HumansMaleRatsRats, Sprague-DawleyFluorodeoxyglucose F18Ischemic strokeMicrogliaNeural stem cell transplantationPositron emission tomographySynapse

Identifiers

PMID42435204

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