Evidence map›Paper›PMID 42435179›Full record

ReviewAdvances in experimental medicine and biology2026

Cysteine Metabolism in the Control of Oxidative Stress in Cancer, Focusing on Carbon and Sulfur Metabolism.

Susana Parreiras, Jacinta Serpa

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Susana ParreirasInstituto de Tecnologia Química e Biológica António Xavier (ITQB NOVA), Avenida da República (EAN), Oeiras, Portugal.
Jacinta SerpaiNOVA4Health, NOVA Medical School | Faculdade de Ciências Médicas, NMS, FCM, Universidade NOVA de Lisboa, Lisboa, Portugal. jacinta.serpa@nms.unl.pt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cysteine is a critical metabolic hub in cancer cells, essential for survival and progression, as it serves as a precursor to glutathione, a key antioxidant that mitigates oxidative stress and contributes to chemoresistance. Beyond antioxidation, cysteine metabolism supports cancer growth by generating metabolic intermediates such as pyruvate and hydrogen sulfide (H

Indexed as

CarbonCysteineNeoplasmsOxidative StressSulfurAnimalsEnergy MetabolismHumansHydrogen SulfideMetabolic ReprogrammingReactive Oxygen SpeciesSignal TransductionCarbonCysteineHydrogen SulfideReactive Oxygen SpeciesSulfur3-mercapto-pyruvate sulfurtransferase (MST)Carbon metabolismCystathionine β-synthase (CBS)Cystathionine γ-lyase (CSE)CysteineCysteine dyoxigenase (CDO)Hydrogen sulfide (H2S)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.