Evidence map›Paper›PMID 42435171›Full record

ReviewAdvances in experimental medicine and biology2026

Immunity and Beyond: Emerging Roles of Monocytes and Macrophages in Cancer.

Ana Tomás, Marta Pojo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ana TomásUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Marta PojoUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal. martapojo@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monocytes and macrophages are key regulators of cancer progression, exhibiting remarkable plasticity. Classically involved in initiating pro-inflammatory responses against tumors, these cells can be co-opted by the tumor microenvironment to adopt immunosuppressive, pro-tumoral phenotypes. Beyond immune modulation, monocytes and macrophages also contribute to cancer progression by promoting angiogenesis, establishing metastatic niches, reactivating dormant tumor cells, and modulating tumor behavior through metabolic and epigenetic mechanisms. Here, we review the diverse and dynamic functions of monocytes and macrophages in cancer, and explore therapeutic approaches aimed at harnessing or redirecting their activity.

Indexed as

MacrophagesMonocytesNeoplasmsTumor-Associated MacrophagesTumor MicroenvironmentAnimalsEpigenesis, GeneticHumansNeovascularization, PathologicAngiogenesisCell metabolismEpigeneticsImmunotherapyMacrophagesMetastatic nicheMonocytesPlasticityTumor-associated macrophagesTumor cell dormancy

Identifiers

PMID42435171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.