ReviewCell biology international2026
The Landscape of BRCA1-Associated Post-Translational Modifications.
Review in Cell biology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BRCA1-BARD1 complex is a vital protein that promotes homologous recombination, acting through its E3 ubiquitin ligase activity. Although ubiquitination remains its only confirmed enzymatic function, emerging evidence suggests that the complex influences a broad range of post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and PARylation, involving other proteins. This review examines findings from various eukaryotic biological models to elucidate how BRCA1 regulates key PTMs. We explore how BRCA1 shapes chromatin architecture by modulating key PTMs such as ubiquitination, methylation, and acetylation. While BRCA1-driven changes in methylation appear to have widespread effects throughout the cell, its influence on ubiquitination and acetylation tends to be more region- or site-specific. Furthermore, this review discusses BRCA1's role in modifying specific target proteins, such as PLK-1, Aurora A, and p53, and explores its involvement in non-ubiquitin PTMs. Beyond its well-established role in DNA repair, BRCA1 also contributes to other cellular processes involving non-ubiquitin PTMs, such as in meiotic sex chromosome inactivation, which is also detailed in this review. Collectively, this review expands the functional landscape of BRCA1 beyond DNA repair, providing new insights into its regulatory impact across various post-translational pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.