ReviewJournal of animal science2026
Porcine Leydig cells: central regulators of boar reproductive development and fertility.
Review in Journal of animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leydig cells within the interstitium of the testis produce the sex steroids (e.g., testosterone and 17β-estradiol), which are essential to male fertility. Unlike most species, pigs have three distinct phases of Leydig cell development and function. The first transient phase occurs during early fetal life, leading to the production of testosterone, which is critical for sex differentiation and early testicular development. The second transient phase in Leydig cell development occurs during the perinatal/neonatal period; during this developmental window, gonadal steroids further masculinize the brain and regulate testicular development. The final phase of Leydig cell development begins prior to puberty, between 100 and 130 d of age. The adult Leydig cell population remains active throughout adulthood. Steroidogenesis within adult Leydig cells is classically stimulated by luteinizing hormone synthesized and released from the anterior pituitary gland. Porcine Leydig cells produce androgens, as well as relatively high concentrations of estrogens, via the Δ5 pathway. Steroidogenesis is reliant on both acute (mobilization of cholesterol and activity of steroid acute regulatory protein [StAR]) and chronic (upregulation of gene expression, organelle expansion, and cell proliferation) responses. Many proteins and enzymes are involved in driving steroidogenesis within Leydig cells, including StAR, CYP11A1, CYP17A1, 3β-HSD, 17β-HSD, and CYP19A3. The production of gonadal steroids by adult Leydig cells is essential for numerous reproductive processes, including spermatogenesis, sperm maturation within the epididymis, accessory sex gland function, and libido. Thus, Leydig cells are critical regulators of boar fertility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.