ArticleFrontiers in oncology2026
Quercetagetin-rich flavonoids from marigold induce apoptosis inhibit metastasis of non-small cell lung cancer via the p53/p21 signaling pathway.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic efficacy and severe side effects associated with conventional chemotherapy, creating an urgent need for safe and effective natural anti-tumor agents. Quercetagetin-rich marigold flavonoids (QG-MF), isolated from the lutein-extracted inflorescence residues of Aim of the study: This study aimed to investigate the Methods: Results: QG-MF significantly suppressed proliferation, migration and invasion, and induced apoptosis as well as cell cycle arrest in A549 and H661 cells in a concentration-dependent manner. Mechanistically, QG-MF upregulated the expression of p53, p21, Bax and caspase-3, and downregulated Bcl-2 in NSCLC cells. Furthermore, siRNA-mediated p53 silencing effectively abrogated the anti-proliferative and pro-apoptotic effects of QG-MF on NSCLC cells. Conclusion: Our findings demonstrate that QG-MF exerts potent anti-NSCLC activity by inducing apoptosis and inhibiting proliferation/metastasis via the p53/p21 signaling pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.