Normal tissue complication probability model of temporal lobe injury following re-irradiation of CIRT for local recurrent nasopharyngeal carcinoma.

Xiyin Guan, Jiayao Sun, Jiyou Peng, Xing Xing, Chaosu Hu

Abstract read

In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiyin Guan *Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.

Jiayao Sun *Shanghai Key Laboratory of Radiation Oncology, Shanghai, China.

Jiyou PengShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China.

Xing XingShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China.

Chaosu HuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Temporal lobe injury (TLI) is a significant complication after carbon-ion re-irradiation (reRT-CIRT) for locally recurrent nasopharyngeal carcinoma (rNPC). This study established normal tissue complication probability (NTCP) models for TLI based on (1) the second-course CIRT dose alone and (2) the cumulative dose of both radiotherapy courses, with the goal of defining clinically applicable, modality-specific dose constraints. Methods and materials: Eighty-nine rNPC patients who underwent reRT-CIRT between 2016 and 2020 were retrospectively analyzed. Deformable image registration transferred initial IMRT dose distributions onto CIRT planning scans, and voxel-wise cumulative equivalent doses in 2-Gy fractions (EQD Results: TLI occurred in 27 patients (30.3%), predominantly unilateral (24/27); 14 were Grade 1 (asymptomatic, MRI-detected only), 7 Grade 2, 5 Grade 3, and 1 Grade 4. The second-course D Conclusion: A CIRT-specific NTCP model based on the second-course D

Indexed as

carbon ion radiotherapynormal tissue complication probability modelrecurrent nasopharyngeal carcinomare-irradiationtemporal lobe injury

Identifiers

PMID42434735

DOI10.3389/fonc.2026.1853143

PMCPMC13349748

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.