ReviewFrontiers in cell and developmental biology2026
MicroRNA-mediated regulation of hair follicle regeneration: mechanisms, delivery strategies, and translational perspectives.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- JAK Inhibitors for Alopecia Areata: Approved Therapies, Efficacy, and Unanswered Questions.Drug design, development and therapy · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hair regeneration depends on a complex interplay between the activation of hair follicle stem cells (HFSCs), maintenance of inductive capacity in the dermal papilla (DP), and the re-establishment of immune microenvironmental homeostasis. Collectively, this interplay underlies a fundamental 'restart' of a multicellular regenerative network. In their role as post-transcriptional regulators, micro-RNAs (miRNAs) exert network-level control over cell fate transitions, paracrine signaling, inflammatory thresholds, and fibrotic processes via the RNA-induced silencing complex (RISC). For this reason, miRNAs have emerged in recent years as key targets for hair regenerative therapies. Recent studies indicate that miRNAs enhance HFSC entry into the active growth phase (i.e., anagen) through pro-regenerative signaling pathways such as Wnt/β-catenin and Sonic hedgehog (Shh), while also mediating the initiation of catagen phase via TGF-β/BMP signaling, extracellular matrix remodeling, and androgen receptor (AR)-associated regressive signaling. In some immune-mediated alopecias (e.g., alopecia areata), miRNA regulation of inflammatory axes, including IFN-γ/JAK-STAT and NF-κB, provides additional therapeutic targets that could potentially be exploited to restore hair follicle immune privilege. In this context, miRNA mimics and inhibitors (e.g., antagomirs and locked nucleic acids, LNAs) enable gain-of-function or blockade, respectively, providing tools that can be used individually or as combined regimens to stimulate regeneration simultaneous with anti-regression/immune remodeling. Recent developments using chemical modifications (e.g., 2'-O modifications, 2'-F, and LNA) improve nucleic-acid stability and modulate RISC loading. From a delivery standpoint, lipid nanoparticles, polymeric nanocarriers, exosome mimetics, and physical enhancement strategies such as microneedles and iontophoresis may help overcome the skin barrier and exploit the follicular "reservoir effect" for localized targeting. Major barriers to clinical translation remain, however, including off-target and network side effects arising from miRNAs' multi-cellular roles
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.