Evidence map›Paper›PMID 42434631›Full record

ArticleCureus2026

Retrospective Analysis of a WashU-Based Knowledge-Based Planning (KBP) Model for Breast and Chest Wall Planning in Guatemala: Compliance With American Society for Radiation Oncology (ASTRO) 2026 Guidelines.

Milton E Ixquiac Cabrera, Erick O Montenegro, Matthew Schmidt, Baozhou Sun, James A Kavanaugh, Taoran Li, Angel Velarde, Vicky de Falla, Francisco Reynoso

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Milton E Ixquiac CabreraSchool of Physical and Mathematical Sciences, Universidad de San Carlos de Guatemala, Guatemala, GTM.
Erick O MontenegroRadiotherapy, Liga Nacional Contra el Cáncer, Guatemala, GTM.
Matthew SchmidtRadiation Oncology, Washington University School of Medicine, St. Louis, USA.
Baozhou SunMedical Physics, Baylor College of Medicine, San Antonio, USA.
James A KavanaughRadiation Oncology, Mayo Clinic, Rochester, USA.
Taoran LiDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, USA.
Angel VelardeOncology, Oncological Hospital Incan, Guatemala, GTM.
Vicky de FallaRadiotherapy, Liga Nacional Contra el Cáncer, Guatemala, GTM.
Francisco ReynosoMedical Science Liaison, Varian Medical Systems, Schiller Park, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/purpose Breast cancer is among the most prevalent malignancies treated at the Liga Nacional Contra el Cáncer (LNCC) in Guatemala, representing a significant proportion of annual radiotherapy cases. Access to high-quality, standardized treatment planning in resource-constrained settings remains a critical challenge. This study evaluates the dosimetric performance of knowledge-based planning (KBP) models adapted from Washington University (WashU) in St. Louis for breast and chest wall radiotherapy at LNCC, validated against a retrospective 2025 clinical cohort, and benchmarked against the ASTRO 2026 Practical Radiation Oncology guidelines. Materials and methods A retrospective analysis of 84 treatment plans (40 left, 44 right) for whole-breast or chest-wall treatment with regional nodal involvement was performed. All patients were treated using volumetric modulated arc therapy (VMAT) under a moderate hypofractionation scheme (40.05 Gy in 15 fractions). KBP models were developed during 2022-2024 using Eclipse V18.0 (Varian Medical Systems, Palo Alto, CA) RapidPlan

Indexed as

astro guidelinesbreast cancerchest walldosimetric qualityhypofractionationknowledge-based planninglow- and middle-income countriesrapidplanvmat

Identifiers

PMID42434631
PMCPMC13353905

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.