ArticleNature reviews. Methods primers2025
Diversity Oriented Clicking for Modular Synthesis.
Article in Nature reviews. Methods primers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Accelerate Your Science: Direct-to-Biology Strategies in Medicinal Chemistry.Journal of medicinal chemistry · 2026Review
- Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.Nature communications · 2026Article
- Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistantbioRxiv : the preprint server for biology · 2026Article
- Bifunctional Aziridines from Photochemically Generated FSOAngewandte Chemie (International ed. in English) · 2026Article
- Accessing trifluoromethylated SuFEx-able pyrazoleRSC advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Diversity Oriented Clicking (DOC) fuses the reliability of classical click reactions with the versatility of Fluoride Exchange (FEx) chemistry, in which fluorine atoms bound to sulfur or phosphorus serve as highly selective reaction handles. This integrated platform forms covalent bonds rapidly and under mild, biocompatible conditions, broadening the synthetic toolkit for building molecular complexity. By employing DOC workflows, researchers can create structurally diverse compound libraries and explore previously inaccessible regions of chemical space. DOC holds particular promise in drug discovery where it accelerates the profiling of protein function in disease contexts and streamlines the design, synthesis, and high-throughput screening of novel therapeutic candidates.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.