ArticleFrontiers in microbiology2026
Microbe-driven flavonoid biotransformation revealed by multi-omics analysis during Hua Feng Dan Yao Mu fermentation.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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- Influence of Methoxy Substitution Pattern on Cascade Biotransformation of 4'-Hydroxychalcones by Entomopathogenic Fungi.International journal of molecular sciences · 2026Article
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Abstract
Microbes play an important role in the transformation of bioactive components in traditional Chinese medicine (TCM) fermentation. It is not understood how the microbial succession relates to the changes in active components of Hua Feng Dan Yao Mu (HFDYM) fermentation. This study systematically characterized the chemical and microbial dynamics during HFDYM fermentation, using multi-omics analyses, with a focus on flavonoid transformation. Single-strain fermentation identified specific microorganisms involved in flavonoid metabolism. During fermentation, there were significant abundance changes in 60 flavonoids. Metabolic pathway analysis revealed a distinct remodeling of flavonoid metabolism, marked by increased levels of (+)-catechin and naringin alongside decreases in many other flavonoids. The analysis of the microbial community showed that the dominant bacterial genera were
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